An evaluation of the thermodynamics of binding between various ligands of Vancomycin (Part 2/2) by Matthew Guberman-Pfeffer* Part 1 in this series can be found here on The Offset and also at the Winnower. Vancomycin Molecular Recognition Events (cont’d) Conversion of the C-terminal D-Ala to D-Lac in the bacterial peptide target results in the loss of one […]

Some of the most rewarding moments in my professional career have been in the midst of protracted conversation with a colleague about some concept or how to communicate an idea to an audience. At times I’ve been the teacher and other times the learner, but the best is when somehow, almost through the strength of […]

An evaluation of the thermodynamics of binding between various ligands of Vancomycin (Part 1/2) by Matthew Guberman-Pfeffer* This post is also published on The Winnower under DOI:10.15200/winn.144060.03577 In Brief The longstanding invincibility of vancomycin (VC) – the last line of antimicrobial therapy for life-threatening Gram-positive infections – has been compromised over the past decade. The most common and […]

A collection of well-written communications reporting the total synthesis of natural product target compounds.